Outcomes of drug (paclitaxel) coated balloons in various coronary lesion subsets; A two-year follow-up study.

Authors

  • Salman Ishaque Shaikh Tabba Heart Institute, Karachi-Pakistan
  • Bashir Hanif Tabba Heart Institute, Karachi-Pakistan
  • Abdul Salam Majeed Agha Tabba Heart Institute, Karachi-Pakistan
  • Hasan Sohail Tabba Heart Institute, Karachi-Pakistan
  • Syed Husban Ali Tabba Heart Institute, Karachi-Pakistan
  • Muhammad Amin Tabba Heart Institute, Karachi-Pakistan

Keywords:

Paclitaxel, Drug-Coated Balloon Angioplasty, MACE.

Abstract

Background: Drug-coated balloons (DCB) are a promising treatment for coronary artery disease (CAD), but their long-term efficacy in different lesion subsets is unknown. This study assessed the clinical outcomes of paclitaxel-coated balloons over two years, examining various lesion types and patient characteristics.

Methodology: This retrospective cohort study analyzed 102 patients who underwent drug-coated balloon (DCB) treatment for denovo or restenotic lesions. Paclitaxel-eluting balloons were utilized, and the primary objective was to assess the occurrence of major adverse cardiovascular events (MACE), defined as death, myocardial infarction, target lesion revasculariazation, and target vessel revascularization at different time intervals. Secondary outcomes, including target lesion failure (TLF), target lesion revascularization (TLR), target vessel revascularization (TVR), and target vessel myocardial infarction (TVMI), were also evaluated. Statistical analysis was conducted using SPSS version 22.0.

Results: In this study, the mean age of the participants was 58.49 years, with the majority being male (81.4%). Lesion types included both de novo (49.0%) and in-stent restenosis (ISR) (51.0%). Bifurcation lesions were present in 29.4% of cases, and ostial lesions were observed in 40% of cases. Thrombus was found in 4.9% of cases. The occurrence of MACE was low, with one patient experiencing MACE at 30 days, nine patients between 30 days and 1 year, and six patients between 1 and 2 years. The overall rates of TLF, TLR, TVR, and TVMI were also low. Some patient characteristics, such as diabetes, dyslipidemia, chronic kidney disease (CKD), and dialysis, were associated with a higher risk of MACE. Importantly, no significant differences in outcomes were observed between various lesion subsets and presentations.

Conclusion: DCB proves to be a viable and efficient treatment option for different types of coronary lesions. The occurrence rates of MACE, TLR, TLF, TVR, and cardiac death following the use of DCB are low.

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Published

01.12.2023

How to Cite

Shaikh, S. I., Hanif, B., Majeed Agha, A. S., Sohail, H., Ali, S. H., & Amin, M. (2023). Outcomes of drug (paclitaxel) coated balloons in various coronary lesion subsets; A two-year follow-up study. Pakistan Journal of Cardiovascular Intervention, 3(2), 01–12. Retrieved from https://pjcvi.com/index.php/ojs/article/view/63