Pakistan Journal of Cardiovascular Intervention 2023-09-13T08:10:02+00:00 Open Journal Systems <p><strong>Pakistan Journal of Cardiovascular Intervention (PJCVI)</strong> is biannual, open access, peer-reviewed journal of the Pakistan Society of interventional cardiology. The journal publishes original research, reviews, short communication, case studies, commentaries and editorials focusing on interventional procedures and techniques. PJCVI provides a platform for determined cardiologists to stay relevant in diagnosing and analyzing, researching, and managing patients with cardiovascular disease and its allied complications.</p> <p><br />The field of interventional cardiology is briskly evolving with innovation and technological progress. The profile of interventional cardiology has risen to the extent that it is now one of the most dynamic subspecialties in mainstream medical practice with the help of experts in molecular biology, biomedical engineering, biophysics and imaging technology. The journal will provide a platform for annotation, discussion and new findings.</p> Outcomes of drug (paclitaxel) coated balloons in various coronary lesion subsets; A two-year follow-up study. 2023-09-13T08:03:27+00:00 Salman Ishaque Shaikh Bashir Hanif Abdul Salam Majeed Agha Hasan Sohail Syed Husban Ali Muhammad Amin <p><strong>Background:</strong> Drug-coated balloons (DCB) are a promising treatment for coronary artery disease (CAD), but their long-term efficacy in different lesion subsets is unknown. This study assessed the clinical outcomes of paclitaxel-coated balloons over two years, examining various lesion types and patient characteristics.</p> <p><strong>Methodology:</strong> This retrospective cohort study analyzed 102 patients who underwent drug-coated balloon (DCB) treatment for denovo or restenotic lesions. Paclitaxel-eluting balloons were utilized, and the primary objective was to assess the occurrence of major adverse cardiovascular events (MACE), defined as death, myocardial infarction, target lesion revasculariazation, and target vessel revascularization at different time intervals. Secondary outcomes, including target lesion failure (TLF), target lesion revascularization (TLR), target vessel revascularization (TVR), and target vessel myocardial infarction (TVMI), were also evaluated. Statistical analysis was conducted using SPSS version 22.0.</p> <p><strong>Results:</strong> In this study, the mean age of the participants was 58.49 years, with the majority being male (81.4%). Lesion types included both de novo (49.0%) and in-stent restenosis (ISR) (51.0%). Bifurcation lesions were present in 29.4% of cases, and ostial lesions were observed in 40% of cases. Thrombus was found in 4.9% of cases. The occurrence of MACE was low, with one patient experiencing MACE at 30 days, nine patients between 30 days and 1 year, and six patients between 1 and 2 years. The overall rates of TLF, TLR, TVR, and TVMI were also low. Some patient characteristics, such as diabetes, dyslipidemia, chronic kidney disease (CKD), and dialysis, were associated with a higher risk of MACE. Importantly, no significant differences in outcomes were observed between various lesion subsets and presentations.</p> <p><strong>Conclusion:</strong> DCB proves to be a viable and efficient treatment option for different types of coronary lesions. The occurrence rates of MACE, TLR, TLF, TVR, and cardiac death following the use of DCB are low.</p> 2023-09-13T00:00:00+00:00 Copyright (c) 2023 The Author Virtual histology of coronary arteries using intravascular ultrasound (IVUS) - local experience. 2023-09-13T08:10:02+00:00 Ahmad Fawad Tayyaba Durrani Hamid Mehmood Sundal Aziz Mohammad Hafizullah <p><strong>Background:</strong> In the occurrence of coronary events, atherosclerotic plaque characteristics have been demonstrated to play a pivotal role. Based on histological studies of victims of sudden cardiac death, lesions containing a large amount of necrotic core with an overlying thin fibrous cap (referred to as thin cap fibroatheroma TCFA) have been linked to plaque rupture. In vivo detection of potentially vulnerable plaques may improve the prevention of cardiovascular events.</p> <p>The aim of the study was to find out the pattern of plaque morphology using VH-IVUs in our population.</p> <p><strong>Methodology:</strong> This descriptive study was conducted in Lady Reading Hospital, Peshawar. We enrolled patients with a history of coronary artery disease admitted for coronary angiography from 2007 to 2011. Virtual histology was obtained for the fibrofatty, fibrous, calcified, and necrotic plaques. The sizes of the vessels and lumen were measured. The results of the study were mentioned in mean, standard deviation, and percentage of different variables.</p> <p><strong>Results:</strong> A total of 41 patients were studied.&nbsp; The mean age was 56.3 years (+ 9.9 SD). Males were 29 (70.7%). Chest pain was almost reported by all patients (100%). Acute coronary syndrome (ACS) diagnosis was present in 23 patients (56.1%), while patients with chronic coronary syndrome (CCS) were 18 (43.9%). The Minimum plaque burden was 58.5%, while the maximum was 89.6%, with a mean value of 73.1%. The most common plaque type was fibrous (77.3% SD +6.4), followed by fibro¬fatty plaque (13.02% SD +3.5). The necrotic type was 7.09 % SD +6.2, while calcified plaque was 2.2% SD + 1.4.</p> <p><strong>Conclusion:</strong> Fibrous type plaque was the most common type of VH IVUS in both CCS patients and the ACS group; However, necrotic core was comparatively more in the ACS group.</p> 2023-09-13T00:00:00+00:00 Copyright (c) 2023 The Author